Female Bloodsugar Support scientifically supplements the diet with nutrients that are particularly important for healthy insulin sensitivity for healthy blood sugar levels. Healthy insulin sensitivity is especially important for women. This is because poor insulin sensitivity is very likely to have a negative impact on fertility.

In fact, it has been found in a wide variety of gold standard studies and major scientific reviews that poor insulin sensitivity is particularly common in women with PCOS; quite independent of body weight. At the same time, it has been found that normalizing insulin sensitivity with the help of certain nutrients can have positive effects on fertility.

Since PCOS is therefore associated with reduced insulin sensitivity in the vast majority of women and is one of the most common hormonal disorders in actually fertile women - the prevalence worldwide is up to 22% - and one can achieve positive effects here through diet and exercise, Female Bloodsugar Support was developed. To perfectly support healthy insulin sensitivity in women with poor insulin sensitivity and thus contribute to healthy fertility.

But what does insulin resistance have to do with fertility anyway? Insulin resistance causes an excess of insulin to be produced, as the insulin present in normal amounts can no longer work properly. Excess insulin, in turn, promotes the production of male hormones and this, in turn, promotes PCOS. Insulin sensitivity, however, can be positively influenced by diet, nutritional supplementation and exercise - and thus also PCOS. Conversely, a poor diet high in sugar and simple carbohydrates, nutrient deficiencies and lack of exercise are the main causes of insulin resistance.

Chromium picolinate, vitamin D, myo- and D-chiro-inositol, and L-carnitine have been found to have direct positive effects on insulin sensitivity. The same is true for exercise. Indirect positive effects can be derived for the patented ashwagandha root extract KSM-66®.

Female Bloodsugar Support is therefore the perfect complement to a healthy, low-sugar diet and exercise to meet the increased need for inositols, chromium, vitamin D as well as L-carnitine in poor insulin sensitivity.

Female Bloodsugar Support is based on current scientific evidence and was developed in conjunction with nutritionists. The dosages of the ingredients correspond to generally accepted scientific data. They have been adapted for the specific needs of women with reduced insulin sensitivity and resulting PCOS.

 

Ingredients

Chrom

One nutrient is particularly important for insulin to work normally: chromium in the form of chromium picolinate. It has been shown to act as an enhancer of insulin. This is why EFSA has also confirmed that chromium has an important role in maintaining healthy blood glucose levels.

And that's why systematic reviews, studies that have looked at trials, have found an association between chromium picolinate supplementation and normalization of fasting insulin levels and testosterone levels in women with PCOS.

Therefore, an important approach is to normalize blood sugar control, to which chromium picolinate has been proven to contribute. Female Bloodsugar Support contains for this reason chromium and vitamin C in the best bioavailability work and effective as well as safe dosage. Vitamin C serves to ensure that the chromium picolinate is effectively absorbed.

 

Vitamin D

It has also been found that there are vitamin D receptors in the pancreas and that insulin resistance and even diabetes are often associated with vitamin D deficiency. So it is also essential to bring the vitamin D level to an optimal level.

That is why Female Bloodsugar Support also contains vitamin D to perfectly cover the increased need in combination with the Essentials.

 

Myo- and D-chiro-inositol

In addition, it has been shown that the need for inositol in the form of myo- and D-chiro-inositol is increased in women with PCOS due to poor insulin sensitivity. Therefore, it makes sense to supply the increased requirement through dietary supplementation.

Among the inositol forms, the combination of myo- and D-chiro-inositol in the proven best ratio of 40:1 has proven particularly effective. Exactly in this ratio and in scientifically effective dosage both substances are present in the body.

 

 

L-Carnitin

In women with PCOS due to poor insulin sensitivity, lower L-carnitine concentrations were frequently found compared to healthy women, regardless of obesity. Possible causes are seen in a disturbance in the formation of L- carnitine, which increases the requirement via the diet. Since L-carnitine is found almost exclusively in meat, women often do not consume enough L-carnitine.

In various studies according to the gold standard (randomized, placebo-controlled double-blind studies) and scientific reviews, positive effects on body weight, BMI, fasting blood glucose and insulin levels were found in women with PCOS when L-carnitine was supplemented, all of which are relevant parameters in PCOS and could be normalized via targeted dietary supplementation.

 

 

Ashwagandha Root Extract

Lastly, ashwagandha root extract is included as patented KSM-66®. Here there is still no concrete data on insulin sensitivity and PCOS. However, it is the case that the plant substance in ashwagandha root can have a positive influence on cortisol levels. Chronically elevated cortisol levels have a negative effect on insulin sensitivity and body weight. Poor insulin sensitivity is known to be the cause of PCOS in the majority of cases. That is why Female Bloodsugar Support also contains KSM-66® in the right dosage.

 

Important: The positive effect on testosterone levels in men is not due to a direct effect on testosterone production, but to the positive effect on increased chronic cortisol levels. Namely, chronically elevated cortisol lowers testosterone levels in men. In women, KSM-66® was not found to increase testosterone levels.

Scientific correlations in detail

Myo- and D-chiro-inositol

Inositol is a vitamin iodine (vitamin-like substance) and plays an important role in many metabolic processes. It occurs naturally in many animal and plant foods and can be synthesized in limited amounts from glucose.

The inositol derivative glycosylphosphatidylinositol (GPI) can bind hormones such as follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH) and also insulin to the cell membrane.

In connection with PCOS, positive effects on inuslin resistance and glucose metabolism as well as a reduction in the level of male sex hormones (androgens) have been observed in various studies according to the gold standard (randomized, placebo-controlled double-blind studies), in particular through the combination of myo-inositol and D-chiro-inositol in a 40:1 ratio present in the human body. In the liver, myo-inositol primarily mediates the uptake of glucose into the body's cells; D-chiro-inositol promotes glycogen synthesis. In addition, myo-inositol is important in the ovaries for the action of FSH; D-chiro-inositol for the insulin-dependent production of androgens. Complementary positive effects on oocyte quality were found. (Roseff & Montenegro, 2020; Egarter, 2019; Dinicola et al., 2014).

Female Bloodsugar Support provides myo-inositol and D-chiro-inositol in the scientifically established sensible ratio of 40:1 and in the nutritionally sensible dosage of 4 g myo-inositol plus 100 mg D-chiro-inositol.

 

L-Carnitine

L-carnitine is a vitaminoid (vitamin-like substance) and plays an important role in particular within fat metabolism and glucose utilization. It occurs as a natural component mainly in animal foods and can be formed in limited quantities from the essential amino acids L-lysine and L-methionine. However, the ability to form it may be impaired, which is why L-carnitine must be adequately supplied through the diet.

L-carnitine generally regulates nutrient utilization between fatty acids and glucose and, in its function as a biocarrier, transports long-chain fatty acids through the cell membrane into the interior of the mitochondria, where they can be utilized for energy. (Biesalski et al., 2017; Luppa, 2004; Gröber, 2011).

Women with PCOS were frequently found to have lower L-carnitine concentrations compared to healthy women, regardless of obesity. (Maleki et al. 2019) Possible causes are thought to be a disturbance in the formation and reabsorption of L-carnitine, which increases dietary requirements. (Rajska et al., 2020)

Several gold-standard (randomized, placebo-controlled, double-blind) studies have found positive effects on body weight, BMI, fasting blood glucose, and insulin levels in women with PCOS when supplementing with L-carnitine, all of which are relevant parameters in PCOS. (Maleki et al. 2019; Salehpour et al., 2019)

Female Bloodsugar Support provides L-carnitine tartrate and acetyl-L-carnitine in the science-based dosage of 250 mg each.

 

Chromium and vitamin C

Chromium is a trace element that plays an important functional role in the regulation of glucose homeostasis and insulin metabolism. Vitamin C belongs to the group of water-soluble vitamins. Both occur as natural components in animal and plant foods.

Among other things, chromium potentiates cellular insulin action and improves glucose tolerance. In this context, vitamin C increases chromium uptake. (Gröber, 2011; Zimmermann et al., 2018; Biesalski et al., 2018).

In this context, a systematic review with meta-analysis of gold-standard studies (randomized, placebo-controlled, double-blind trials) in women with PCOS and lowered insulin sensitivity stated positive effects on insulin sensitivity, glucose tolerance, BMI, and also acne and unusual body hair, particularly for chromium picolinate in a dosage of 200 mcg of elemental chromium. (Fazelian et al., 2017)

Female Bloodsugar Suppert provides chromium as a well-bioavailable chromium picolinate combined with vitamin C to enhance bioavailability at the scientifically established dosage of 200 mcg chromium plus 50 mg vitamin C.

 

Vitamin D

Vitamin D is a steroid hormone of the human body and is present in almost all tissues of the female reproductive tract. It is synthesized from cholesterol primarily in the skin by its exposure to sunlight. It is also found in limited quantities in animal and occasionally in plant foods.

Vitamin D has a function in insulin production. Vitamin D deficiency increases the risk of inuslin resistance, according to epidemiological and interventional studies. (Holick & Gröber, 2019) In addition, vitamin D receptors are found in the ovaries and endometrium (Voulgaris et al., 2017).

Women with PCOS have been found to be particularly deficient in vitamin D in studies compared to the rest of the population, which scientific evidence suggests may play a role in exacerbating PCOS. (Thomson et al., 2012)

A systematic review with meta-analysis of gold standard (randomized, placebo-controlled, double-blind) studies states that current evidence suggests that exogenous vitamin D supplementation may ameliorate vitamin D deficiency and be beneficial for follicular development and regulation of the menstrual cycle. (Fang et al; 2016)

Female Bloodsugar Support provides vitamin D as a well-bioavailable vitamin D3 (cholecalciferol) to meet increased needs in combination with Essentials.